反应详情

To a suspension of 5-bromo-2-hydroxy-3-methyl pyridine A1 (1.000 g; 5.053 mmol) and potassium carbonate (1.397 g; 10.105 mmol) in DMF (5.000 ml) is carefully added iodomethane (0.346 ml; 5.558 mmol). The reaction mixture is stirred overnight (16 h) at room temperature. The reaction mixture is then quenched with 10% ammonia solution (10 ml) and 30 ml water is added. It is extracted with 3×50 ml EtOAc. The combined organic layer is dried with Na2SO4, filtered and concentrated under reduced pressure to afford the product.

1. customThe reaction mixture is then quenched with 10% ammonia solution (10 ml) and 30 ml water
2. additionis added
3. extractionIt is extracted with 3×50 ml EtOAc
4. dry with materialThe combined organic layer is dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customto afford the product