Water → HCID 72697849, compound

HRID 930546Notes

Reaction equation

HRID 930546 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH2:12]([NH2:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.CCN(C(C)C)C(C)C.O>CN1C(=O)CCC1>[CH2:12]([NH:19][C:6]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7504BenzylamineHCID 81531DiisopropylethylamineHCID 122757652,4-Dichloro-5-nitropyridine

Product 1

HCID 72697849HCID 72697849, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

To a stirred solution of 2,4-dichloro-5-nitropyridine E-2.1″ (10.000 g; 51.817 mmol) and benzylamine (5.552 g; 51.817 mmol) in NMP is added DIPEA (20.053 g; 155.451 mmol) at 0° C. The mixture is stirred at RT for 1 h. Water is added, precipitation of the product occurs. Product is filtered off and dried under vacuum.

Workup

  1. customprecipitation of the product
  2. filtrationProduct is filtered off
  3. customdried under vacuum

Sources & evidence

ORD record
ord-8581177c91e94e34aee52b7313feaf43
Source dataset
uspto-grants-2016_03
Patent number
US09296748B2

Reaction notes

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