Bis(2-Methoxyethyl)amine → HCID 90014371, compound

HRID 930994Notes

Reaction equation

HRID 930994 reaction equation
[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([OH:17])=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:18][O:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][O:25][CH3:26]>>[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([N:22]([CH2:23][CH2:24][O:25][CH3:26])[CH2:21][CH2:20][O:19][CH3:18])=[O:17])[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 2383Bis(2-Methoxyethyl)amineHCID 179900774-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid

Product 1

HCID 90014371HCID 90014371, compound

Procedure

300 mg (1.12 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using 2-methoxy-N-(2-methoxyethyl)ethanamine to give after working up and purification 340 mg (79%) of the title compound.

Workup

  1. customto give
  2. custompurification 340 mg (79%) of the title compound

Sources & evidence

ORD record
ord-032c9bf5001e4eb68472213357bb2e58
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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