反应详情

To a solution of 6-bromopyridine-2-carbaldehyde (3 g, 16.22 mmol) in toluene (60 mL) was added ethylene glycol (4.97 g, 80.2 mmol) and p-toluenesulphonic acid (0.152 g, 0.8 mmol). The reaction mixture was refluxed for 3 h. The solvent was removed under reduced pressure to afford the crude which was dissolved in ethyl acetate and washed with water. The organic layers were washed with a brine solution, and dried over sodium sulfate. The solvent was removed under reduced pressure to afford 2-bromo-6-(1,3-dioxolan-2-yl)pyridine (3.7 g). The material was used for the next step without further purification.

1. temperatureThe reaction mixture was refluxed for 3 h
2. customThe solvent was removed under reduced pressure
3. customto afford the crude which
4. washwashed with water
5. washThe organic layers were washed with a brine solution
6. dry with materialdried over sodium sulfate
7. customThe solvent was removed under reduced pressure