Trifluoroacetic acid → HCID 89853889, compound

HRID 931099Notes

Reaction equation

HRID 931099 reaction equation
[CH:1]1[N:5]=[C:4]([CH:6]2[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[N:3]2[CH2:19][CH2:20][CH2:21][C:2]=12.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH:8]1[CH2:9][CH2:10][CH2:11][CH:6]([C:4]2[N:3]3[CH2:19][CH2:20][CH2:21][C:2]3=[CH:1][N:5]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117966443HCID 117966443, compound

Product 1

HCID 89853889HCID 89853889, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

t-Butyl 3-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-yl)piperidine-1-carboxylate (65 mg, 0.1 mmol) was dissolved into a 20% trifluoroacetic acid in dichloromethane solution (2.4 mL). The reaction mixture was stirred at room temperature for 2.5 h. The solvent was removed under reduced pressure to afford 3-(piperidin-3-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazole trifluoroacetate salt as an oil (94 mg, 100%). The material was used without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-c1cc411824fc4d73824e92787a8d9940
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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