m-Chloroperbenzoic acid → HCID 89853680, compound

HRID 931129Notes

Reaction equation

HRID 931129 reaction equation
ClC1C=C(C=CC=1)C(OO)=[O:6].[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]2([C:21]([O:23]CC)=[O:22])[CH2:20][CH2:19]2)[CH:13]=1>ClCCl>[C:21]([C:18]1([C:14]2[CH:13]=[N+:12]([O-:6])[CH:17]=[CH:16][CH:15]=2)[CH2:20][CH2:19]1)([OH:23])=[O:22]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 21054369Ethyl 1-(pyridin-3-yl)cyclopropane-1-carboxylate

Product 1

HCID 89853680HCID 89853680, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

70% meta-Chloroperoxybenzoic acid (1.2 g, 4.9 mmol) was added to a solution of ethyl 1-(pyridin-3-yl)cyclopropanecarboxylate (400 mg, 2.4 mmol) in dichloromethane (5 mL) at room temperature and stirred for 16 h. The resulting precipitate was filtered and triturated with dichloromethane to afford the title compound (250 mg).

Workup

  1. filtrationThe resulting precipitate was filtered
  2. customtriturated with dichloromethane

Sources & evidence

ORD record
ord-296c5dbf1f554ca6914be0b18e3bee67
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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