Sodium ethoxide → Ethyl 2-(4-fluoro-1H-pyrazol-1-yl)propanimidate
Reaction equation
[O-:1][CH2:2][CH3:3].[Na+].[Na].[F:6][C:7]1[CH:8]=[N:9][N:10]([CH:12]([CH3:15])[C:13]#[N:14])[CH:11]=1>C(O)C>[F:6][C:7]1[CH:8]=[N:9][N:10]([CH:12]([CH3:15])[C:13](=[NH:14])[O:1][CH2:2][CH3:3])[CH:11]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
To a solution of sodium ethoxide, prepared by adding solid sodium metal (64.4 mg, 2.80 mmol) to ethanol (10 mL), was added a solution of 2-(4-fluoro-1H-pyrazol-1-yl)propanenitrile (390 mg, 2.80 mmol) in ethanol (2 mL). The reaction mixture was stirred at 70° C. for 18 h. The mixture was cooled to room temperature and used without further purification. MS (EI+) (M+) 186; GCMS retention time: 1.27 min (Method O).
Workup
- temperatureThe mixture was cooled to room temperature
- customused without further purification
Sources & evidence
- ORD record
- ord-a66abe6a925b4fa3b9adec3526954be7
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09296745B2
Reaction notes
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