Ethanol → HCID 117966583, compound

HRID 931159Notes

Reaction equation

HRID 931159 reaction equation
[Na].[N:2]1([C:7]2([C:10]#[N:11])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[N:3]1.[CH2:12]([OH:14])[CH3:13]>>[N:2]1([C:7]2([C:10](=[NH:11])[O:14][CH2:12][CH3:13])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 3

HCID 702Ethanol2×HCID 5360545SodiumHCID 89853797HCID 89853797, compound

Product 1

HCID 117966583HCID 117966583, compound

Conditions

Temperature
70 °C

Procedure

Sodium metal (12 mg, 0.52 mmol) was added to anhydrous ethanol (3 mL) at room temperature and the mixture was stirred for 15 min. 1-(1H-pyrazol-1-yl)cyclopropanecarbonitrile (0.1 g, 0.75 mmol) dissolved in ethanol (2 mL) was added and the reaction mixture was heated to 70° C. for 90 min. The resulting solution was used without further purification.

Workup

  1. additionwas added
  2. customThe resulting solution was used without further purification

Sources & evidence

ORD record
ord-3cabb66fe334417aa947b316315a861e
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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