HCID 68277956, compound → HCID 68277995, compound

HRID 931503Notes

Reaction equation

HRID 931503 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1)(=[O:20])=[O:19]>Cl>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1)(=[O:19])=[O:20]

Participants

3

Reactant 1

HCID 68277956HCID 68277956, compound

Product 1

HCID 68277995HCID 68277995, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl 4-(5-methyl-4-((4-(morpholinomethyl)phenylsulfonyl)methyl)oxazol-2-yl)benzoate (1 g, 2.13 mmol, 1.00 equiv) in 6N hydrochloric acid (40 mL) was refluxed for 8 h. The reaction mixture was cooled to room temperature naturally and then diluted with 100 mL of water/ice. The precipitate was collected by filtration, washed with 2×20 mL of water and dried in a vacuum oven to give 0.7 g (72%) of 4-(5-methyl-4-((4-(morpholinomethyl)phenylsulfonyl)methyl)oxazol-2-yl)benzoic acid as a white solid.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with 2×20 mL of water
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-9b684a99cbf5489a8d99dc77c35ed94c
Source dataset
uspto-grants-2016_03
Patent number
US09296732B2

Reaction notes

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