反应详情

To a stirred solution of (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetic acid (5G) (180 mg, 0.49 mmol) in DMF (15 mL) was added cesium carbonate (321 mg, 0.98 mmol) at 0° C. After being stirred for 10 min iodoethane (0.059 mL, 0.74 mmol) was added. The mixture was stirred at room temperature for 2 hours and quenched by the slow addition of a NaHCO3 solution. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and concentrated. The residue was purified by column chromatography to give the pure product 5H (168 mg, 87%). LCMS-ESI+ (m/z): 394.1, 396.1 (M+H)+.

1. additionwas added
2. customquenched by the slow addition of a NaHCO3 solution
3. extractionThe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with brine
5. customdried
6. concentrationconcentrated
7. customThe residue was purified by column chromatography