Sodium ethoxide → HCID 66630478, compound

HRID 931762Notes

Reaction equation

HRID 931762 reaction equation
[C:1]([O:5][C@@H:6]([C:9]1[C:10]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)=[C:11]2[C:16](=[CH:17][C:18]=1[CH3:19])[N:15]=[C:14]([CH2:20][O:21][CH3:22])[CH:13]=[CH:12]2)[CH2:7][OH:8])([CH3:4])([CH3:3])[CH3:2].[O-][CH2:31]C.[Na+]>C(O)C.CO>[C:1]([O:5][C@@H:6]([C:9]1[C:10]([C:23]2[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=2)=[C:11]2[C:16](=[CH:17][C:18]=1[CH3:19])[N:15]=[C:14]([CH2:20][O:21][CH2:22][CH3:31])[CH:13]=[CH:12]2)[CH2:7][OH:8])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 2723922Sodium ethoxideHCID 66631437HCID 66631437, compound

Product 1

HCID 66630478HCID 66630478, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-2-(ethoxymethyl)-7-methylquinolin-6-yl)ethanol was prepared following the procedure used to prepare compound (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-(methoxymethyl)-7-methylquinolin-6-yl)ethanol of Example 12, except that sodium ethoxide in ethanol solution was used instead of sodium methoxide in methanol solution. LCMS-ESI+ (m/z): 428.2, 430.2 (M+H)+.

Sources & evidence

ORD record
ord-2936ea01431e4781ae53742cdc9e17ba
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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