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HRID931917

反应详情

EQUATION

反应方程式

HRID 931917 的结构方程式

REACTANTS

反应物

3
结构：C=CCBr
HCID7841

Allyl bromide

C3H5Br

结构：C[Si](C)(C)[N-][Si](C)(C)C.[Li+]
HCID2733832

Lithium Hexamethyldisilazide

C6H18LiNSi2

结构：O=C1CC[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1CC1CC1
HCID60154112

未命名化合物

PRODUCTS

生成物

1
结构：C=CC[C@H]1C[C@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O
HCID60154122

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a solution of (5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)piperidin-2-one (1481 mg, 3957 μmol; Example 35, Step A) and allyl bromide (360 μl, 4155 μmol) in THF (16 mL, 0.25 M) was added dropwise lithium bis(trimethylsilyl) amide (1M solution in THF, 4352 μl, 4352 μmol) at −78° C.