反应详情

A mixture of 1-(6-chloropyridin-2-yl)propan-1-ol (0.497 g, 2.90 mmol), CBr4 (1.2 g, 3.62 mmol) and triphenylphosphine (0.987 g, 3.76 mmol) in 25 mL of THF was stirred at room temperature for 2 h. The solid was filtered off and washed with THF. The filtrate was concentrated and residue was purified by chromatography on silica gel, eluting with 10 to 50% EtOAc/hexane to provide the title compound. Mass Spectrum (ESI) m/z=236 (M+1).

1. filtrationThe solid was filtered off
2. washwashed with THF
3. concentrationThe filtrate was concentrated
4. customresidue was purified by chromatography on silica gel
5. washeluting with 10 to 50% EtOAc/hexane