Hydrochloric Acid → 1-Ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-methyl-3-trifluoroacetamido-1-azetidinyl)-3-quinolinecarboxylic acid

HRID 932426Notes

Reaction equation

HRID 932426 reaction equation
[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([F:14])[c:11]([F:13])[c:12]12.[CH3:21][C:22]1([NH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32])[CH2:23][NH:24][CH2:25]1.[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[ClH:20].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[CH2:1]([CH3:2])[n:3]1[cH:4][c:5]([C:17](=[O:18])[OH:19])[c:6](=[O:16])[c:7]2[cH:8][c:9]([F:15])[c:10]([N:24]3[CH2:23][C:22]([CH3:21])([NH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32])[CH2:25]3)[c:11]([F:13])[c:12]12

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 8471TriethylamineHCID 98351791-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 200879202,2,2-trifluoro-N-(3-methylazetidin-3-yl)acetamide

Product 1

HCID 117435771-Ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-methyl-3-trifluoroacetamido-1-azetidinyl)-3-quinolinecarboxylic acid

Sources & evidence

ORD record
ord-75a5f93286914b2bad2c0ddf9ec73dfc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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