Dimethylformamide → 5-methoxy-N-[[2-(trifluoromethyl)-1H-indol-5-yl]methyl]pyrazine-2-carboxamide

HRID 932756Notes

Reaction equation

HRID 932756 reaction equation
[CH3:25][O:26][c:27]1[n:28][cH:29][c:30]([C:33](=[O:34])[OH:35])[n:31][cH:32]1.[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[F:45][C:46]([c:47]1[nH:48][c:49]2[cH:50][cH:51][c:52]([CH2:56][NH2:57])[cH:53][c:54]2[cH:55]1)([F:58])[F:59].[O:60]=[CH:61][N:62]([CH3:63])[CH3:64].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[CH3:25][O:26][c:27]1[n:28][cH:29][c:30]([C:33](=[O:35])[NH:57][CH2:56][c:52]2[cH:51][cH:50][c:49]3[nH:48][c:47]([C:46]([F:45])([F:58])[F:59])[cH:55][c:54]3[cH:53]2)[n:31][cH:32]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 457898115-Methoxy-2-pyrazinecarboxylic acidHCID 58126817(2-(Trifluoromethyl)-1h-indol-5-yl)methanamine

Product 1

HCID 444662015-methoxy-N-[[2-(trifluoromethyl)-1H-indol-5-yl]methyl]pyrazine-2-carboxamide

Sources & evidence

ORD record
ord-bdf0f243dd6f47be99508863cfcab5a6
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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