Tetrahydrofuran → 6-(1-Isopropyl-piperidin-4-yloxy)-benzo[b]thiophene-2-carboxylic acid ethyl ester

HRID 933319Notes

Reaction equation

HRID 933319 reaction equation
[CH2:16][CH3:17].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:9]([s:10]1)[cH:11][c:12]([OH:15])[cH:13][cH:14]2.[CH2:61]1[O:62][CH2:63][CH2:64][CH2:65]1.[CH:18]([CH3:19])([CH3:20])[N:21]1[CH2:22][CH2:23][CH:24]([OH:27])[CH2:25][CH2:26]1.[O:47]=[C:48]([O:49][CH:50]([CH3:51])[CH3:52])[N:53]=[N:54][C:55]([O:56][CH:57]([CH3:58])[CH3:59])=[O:60].[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][c:8]2[c:9]([s:10]1)[cH:11][c:12]([O:15][CH:24]1[CH2:23][CH2:22][N:21]([CH:18]([CH3:19])[CH3:20])[CH2:26][CH2:25]1)[cH:13][cH:14]2

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 796811-Isopropylpiperidin-4-olHCID 123138EthylHCID 58047243Ethyl 6-hydroxybenzo[b]thiophene-2-carboxylate

Product 1

HCID 687272376-(1-Isopropyl-piperidin-4-yloxy)-benzo[b]thiophene-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-914764b35f4f453d883fb5e4842392ed
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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