1-Butanol → 5-bromo-2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 933552Notes

Reaction equation

HRID 933552 reaction equation
[Br:1][c:2]1[c:3]([Cl:9])[n:4][c:5]([Cl:8])[n:6][cH:7]1.[CH2:28]([OH:29])[CH2:30][CH2:31][CH3:32].[CH:10]1([c:13]2[cH:14][c:15]([NH2:18])[n:16][nH:17]2)[CH2:11][CH2:12]1.[CH:19]([N:20]([CH:21]([CH3:22])[CH3:23])[CH2:24][CH3:25])([CH3:26])[CH3:27]>>[Br:1][c:2]1[c:3]([NH:18][c:15]2[cH:14][c:13]([CH:10]3[CH2:11][CH2:12]3)[nH:17][n:16]2)[n:4][c:5]([Cl:8])[n:6][cH:7]1

Participants

5

Reactant 4

HCID 2631-ButanolHCID 81531DiisopropylethylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 27580143-cyclopropyl-1H-pyrazol-5-amine

Product 1

HCID 578664465-bromo-2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Sources & evidence

ORD record
ord-43f5f0eceb5840e4b6325d920afb2298
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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