1,2-Dichloroethane → 3-(4-Bromomethyl-3-fluorophenyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

HRID 933661Notes

Reaction equation

HRID 933661 reaction equation
[Br:40][N:41]=[C:42]([OH:43])[CH2:44][CH2:45][C:46]([OH:47])=[O:48].[Cl:1][c:2]1[cH:3][c:4]([C:9]2([C:22]([F:23])([F:24])[F:25])[CH2:10][C:11]([c:14]3[cH:15][c:16]([F:21])[c:17]([CH3:20])[cH:18][cH:19]3)=[N:12][O:13]2)[cH:5][c:6]([Cl:8])[cH:7]1.[Cl:26][c:27]1[cH:28][c:29]([C:30]([C:31]([F:32])([F:33])[F:34])=[CH2:35])[cH:36][c:37]([Cl:38])[cH:39]1.[Cl:61][CH2:62][CH2:63][Cl:64].[N:49]#[C:50][C:51]([N:52]=[N:53][C:54]([C:55]#[N:56])([CH3:57])[CH3:58])([CH3:59])[CH3:60].[OH2:65]>>[Cl:1][c:2]1[cH:3][c:4]([C:9]2([C:22]([F:23])([F:24])[F:25])[CH2:10][C:11]([c:14]3[cH:15][c:16]([F:21])[c:17]([CH2:20][Br:40])[cH:18][cH:19]3)=[N:12][O:13]2)[cH:5][c:6]([Cl:8])[cH:7]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 962WaterHCID 6547AzobisisobutyronitrileHCID 231598135-(3,5-Dichlorophenyl)-3-(3-fluoro-4-methylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazoleHCID 231598231,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzeneHCID 178525505HCID 178525505, compound

Product 1

HCID 231598103-(4-Bromomethyl-3-fluorophenyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

Sources & evidence

ORD record
ord-ffcf63b7d19d4ad58587527afa78f968
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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