Ammonium → 3-[5-Chloro-3-(4-methyl-1-piperazinyl)-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

HRID 933683Notes

Reaction equation

HRID 933683 reaction equation
[CH:26]1([NH2:29])[CH2:27][CH2:28]1.[CH:31]([Mg+:32])([CH3:33])[CH3:34].[Cl-:30].[Cl-:35].[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]2)[c:5](=[O:18])[n:6](-[c:8]2[cH:9][c:10]([C:11](=[O:12])[OH:13])[cH:14][cH:15][c:16]2[CH3:17])[cH:7]1.[NH4+:36].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]2)[c:5](=[O:18])[n:6](-[c:8]2[cH:9][c:10]([C:11](=[O:12])[NH:29][CH:26]3[CH2:27][CH2:28]3)[cH:14][cH:15][c:16]2[CH3:17])[cH:7]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312Chloride2×HCID 8028TetrahydrofuranHCID 69828CyclopropylamineHCID 666890503-[5-Chloro-3-(4-methylpiperazin-1-yl)-2-oxopyrazin-1-yl]-4-methylbenzoic acidHCID 178461726HCID 178461726, compound

Product 1

HCID 666864943-[5-Chloro-3-(4-methyl-1-piperazinyl)-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Sources & evidence

ORD record
ord-1882b174e6224f7daeee3cc9d9b57737
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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