Tetrahydrofuran → Benzyl 3-amino-6-chloro-2-fluorobenzoate

HRID 933725Notes

Reaction equation

HRID 933725 reaction equation
[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:10][CH2:11][CH2:12][CH2:13][Li:14].[Cl:15][Si:16]([CH3:17])([CH3:18])[CH2:19][CH2:20][Si:21]([Cl:22])([CH3:23])[CH3:24].[Cl:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH2:6])[cH:7][cH:8]1.[Cl:25][C:26](=[O:27])[O:28][CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[Cl:1][c:2]1[c:3]([C:26](=[O:27])[O:28][CH2:29][c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:4]([F:9])[c:5]([NH2:6])[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 10387Benzyl chloroformateHCID 835521,2-Bis(chlorodimethylsilyl)ethaneHCID 938984-Chloro-2-fluoroanilineHCID 178418339Butyllithium

Product 1

HCID 58087305Benzyl 3-amino-6-chloro-2-fluorobenzoate

Sources & evidence

ORD record
ord-b1ef9190003a4f61815fa187efcf4761
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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