Hydrochloric Acid → 8-(1-Pyrrolidinyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile
Reaction equation
[CH2:1]1[CH2:2][CH2:3][NH:4][CH2:5]1.[CH2:6]1[CH2:7][O:8][C:9]2([CH2:10][CH2:11][C:12](=[O:15])[CH2:13][CH2:14]2)[O:16]1.[CH3:22][OH:23].[ClH:20].[K:17][C:18]#[N:19].[OH2:21]>>[CH2:1]1[CH2:2][CH2:3][N:4]([C:12]2([C:18]#[N:19])[CH2:11][CH2:10][C:9]3([O:8][CH2:7][CH2:6][O:16]3)[CH2:14][CH2:13]2)[CH2:5]1Participants
7
Sources & evidence
- ORD record
- ord-f5101ebbe9374f8f8e2ae4b17699c1ac
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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