Hydrochloric Acid → N-[4-(6-Chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzyl]-propionamide

HRID 933890Notes

Reaction equation

HRID 933890 reaction equation
[C:10]([CH2:11][CH3:12])(=[O:13])[Cl:14].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[Cl:43][CH2:44][Cl:45].[ClH:15].[NH2:16][CH2:17][c:18]1[c:19]([F:42])[cH:20][c:21]([C:24](=[O:25])[N:26]2[c:27]3[c:28]([cH:37][c:38]([Cl:41])[cH:39][cH:40]3)[NH:29][c:30]3[n:31]([CH3:36])[n:32][cH:33][c:34]3[CH2:35]2)[cH:22][cH:23]1>>[C:10]([CH2:11][CH3:12])(=[O:13])[NH:16][CH2:17][c:18]1[c:19]([F:42])[cH:20][c:21]([C:24](=[O:25])[N:26]2[c:27]3[c:28]([cH:37][c:38]([Cl:41])[cH:39][cH:40]3)[NH:29][c:30]3[n:31]([CH3:36])[n:32][cH:33][c:34]3[CH2:35]2)[cH:22][cH:23]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 62324Propionyl chlorideHCID 81531DiisopropylethylamineHCID 136128347[4-(Aminomethyl)-3-fluorophenyl]-(8-chloro-1-methyl-4,10-dihydropyrazolo[4,5-c][1,5]benzodiazepin-5-yl)methanone

Product 1

HCID 135736058N-[4-(6-Chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-fluoro-benzyl]-propionamide

Sources & evidence

ORD record
ord-e281a50d75ce4931a55406fda4e24229
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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