Ammonia → N-[4-[[4-[[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]carbamoylamino]naphthalen-1-yl]oxymethyl]-2-pyridinyl]-2-methoxypropanamide
Reaction equation
[CH3:66][OH:67].[CH3:68][CH2:69][CH2:70][CH:71]([CH3:72])[CH3:73].[CH3:74][CH2:75][O:76][C:77]([CH3:78])=[O:79].[CH3:7][O:8][CH:9]([C:10](=[O:11])[OH:12])[CH3:13].[CH:53]([N:54]([CH2:55][CH3:56])[CH:57]([CH3:58])[CH3:59])([CH3:60])[CH3:61].[Cl:1][C:2]([N:3]([CH3:4])[CH3:5])=[CH2:6].[Cl:63][CH2:64][Cl:65].[NH2:14][c:15]1[n:16][cH:17][cH:18][c:19]([CH2:21][O:22][c:23]2[cH:24][cH:25][c:26]([NH:33][C:34](=[O:35])[NH:36][c:37]3[cH:38][c:39]([C:49]([CH3:50])([CH3:51])[CH3:52])[n:40][n:41]3-[c:42]3[cH:43][cH:44][c:45]([CH3:48])[cH:46][cH:47]3)[c:27]3[cH:28][cH:29][cH:30][cH:31][c:32]23)[cH:20]1.[NH3:62]>>[CH3:7][O:8][CH:9]([C:10](=[O:12])[NH:14][c:15]1[n:16][cH:17][cH:18][c:19]([CH2:21][O:22][c:23]2[cH:24][cH:25][c:26]([NH:33][C:34](=[O:35])[NH:36][c:37]3[cH:38][c:39]([C:49]([CH3:50])([CH3:51])[CH3:52])[n:40][n:41]3-[c:42]3[cH:43][cH:44][c:45]([CH3:48])[cH:46][cH:47]3)[c:27]3[cH:28][cH:29][cH:30][cH:31][c:32]23)[cH:20]1)[CH3:13]Participants
10
Reactant 9
HCID 222Ammonia
HCID 887Methanol
HCID 6344Dichloromethane
HCID 78922-Methylpentane
HCID 8857Ethyl Acetate
HCID 81531Diisopropylethylamine
HCID 922092-Methoxypropanoic acid
HCID 190103761-chloro-N,N-dimethylethenamine
HCID 584167531-(4-((2-Aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureaProduct 1
Sources & evidence
- ORD record
- ord-3aa2f9442603483e94c8112ae9b92fa8
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…