Methanol → but-2-ynyl 4-(1'-(dimethylcarbamoyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]-1-yl)piperidine-1-carboxylate

HRID 934437Notes

Reaction equation

HRID 934437 reaction equation
[C:34]([O:35][CH2:36][C:37]#[C:38][CH3:39])(=[O:40])[Cl:41].[CH3:1][N:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)[CH3:26].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:49][C:50]#[N:51].[CH3:52][OH:53].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48]>>[CH3:1][N:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][CH2:16][N:17]([C:34]([O:35][CH2:36][C:37]#[C:38][CH3:39])=[O:40])[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]21)[CH3:26]

Participants

7

Reactant 6

HCID 887MethanolHCID 6342AcetonitrileHCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 41316692-Butyn-1-yl chloroformateHCID 24798103N,N-dimethyl-1-(piperidin-4-yl)-2',3'-dihydrospiro[piperidine-4,4'-quinoline]-1'-carboxamide

Product 1

HCID 24797832but-2-ynyl 4-(1'-(dimethylcarbamoyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]-1-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-3c499d3e84ba47d08af81011504c1780
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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