1,2-Dichloroethane → (4-Bromo-6-chloro-quinolin-2-yl)-(2-methoxy-benzyl)-amine

HRID 934711Notes

Reaction equation

HRID 934711 reaction equation
[Br:1][c:2]1[cH:3][c:4]([NH2:13])[n:5][c:6]2[cH:7][cH:8][c:9]([Cl:12])[cH:10][c:11]12.[C:28]([O:29][BH-:30]([O:31][C:32](=[O:33])[CH3:34])[O:35][C:36](=[O:37])[CH3:38])(=[O:39])[CH3:40].[CH3:14][O:15][c:16]1[c:17]([CH:18]=[O:19])[cH:20][cH:21][cH:22][cH:23]1.[CH3:24][C:25](=[O:26])[OH:27].[Cl:42][CH2:43][CH2:44][Cl:45].[Na+:41]>>[Br:1][c:2]1[cH:3][c:4]([NH:13][CH2:18][c:17]2[c:16]([O:15][CH3:14])[cH:23][cH:22][cH:21][cH:20]2)[n:5][c:6]2[cH:7][cH:8][c:9]([Cl:12])[cH:10][c:11]12

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 923Sodium ionHCID 86582-MethoxybenzaldehydeHCID 2724942TriacetoxyborohydrideHCID 576475264-Bromo-6-chloroquinolin-2-amine

Product 1

HCID 68574963(4-Bromo-6-chloro-quinolin-2-yl)-(2-methoxy-benzyl)-amine

Sources & evidence

ORD record
ord-ba0a94daa68a4e8cbfef894c4d077379
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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