Diisopropylamine → 2,2,4,4-Tetramethyl-6-ethynylchroman

HRID 935120Notes

Reaction equation

HRID 935120 reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:13][C:14]1([CH3:29])[O:15][c:16]2[cH:17][cH:18][c:19]([C:26]([CH3:27])=[O:28])[cH:20][c:21]2[C:22]([CH3:24])([CH3:25])[CH2:23]1.[CH3:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[CH:30]([N-:31][CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Li+:37]>>[CH3:13][C:14]1([CH3:29])[O:15][c:16]2[cH:17][cH:18][c:19]([C:26]#[CH:27])[cH:20][c:21]2[C:22]([CH3:24])([CH3:25])[CH2:23]1

Participants

8

Reactant 7

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8058HexaneHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 156611361-(2,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-yl)ethan-1-oneHCID 178418339Butyllithium

Product 1

HCID 156611382,2,4,4-Tetramethyl-6-ethynylchroman

Sources & evidence

ORD record
ord-280aa53590074d579fc5d0fd5ab90c71
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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