Hydrochloric Acid → 4-chloro-3-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidazol-2-one

HRID 935652Notes

Reaction equation

HRID 935652 reaction equation
[CH3:1][S:2]([O:3][CH2:6][CH2:7][CH2:8][n:9]1[c:10](=[O:19])[nH:11][c:12]2[c:13]1[c:14]([Cl:18])[cH:15][cH:16][cH:17]2)(=[O:4])=[O:5].[CH3:42][N:43]([CH3:44])[CH:45]=[O:46].[ClH:20].[F:21][c:22]1[cH:23][cH:24][c:25]([C:28](=[O:29])[CH:30]2[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]2)[cH:26][cH:27]1.[Na+:36].[Na+:37].[O-:38][C:39](=[O:40])[O-:41]>>[CH2:6]([CH2:7][CH2:8][n:9]1[c:10](=[O:19])[nH:11][c:12]2[c:13]1[c:14]([Cl:18])[cH:15][cH:16][cH:17]2)[N:33]1[CH2:32][CH2:31][CH:30]([C:28]([c:25]2[cH:24][cH:23][c:22]([F:21])[cH:27][cH:26]2)=[O:29])[CH2:35][CH2:34]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 923Sodium ion2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 27244404-(4-Fluorobenzoyl)piperidineHCID 214248143-(7-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl methanesulfonate

Product 1

HCID 214248284-chloro-3-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidazol-2-one

Sources & evidence

ORD record
ord-a01a22b62ab04bee9b9ae475caaad253
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…