Ethanol → 5-(5-Chloropyridin-3-ylethynyl)-2-fluorophenylamine

HRID 936547Notes

Reaction equation

HRID 936547 reaction equation
[CH3:27][CH2:28][OH:29].[Cl:8][c:9]1[cH:10][n:11][cH:12][c:13]([C:15]#[C:16][c:17]2[cH:18][c:19]([N+:24]([O-:25])=[O:26])[c:20]([F:23])[cH:21][cH:22]2)[cH:14]1.[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1.[OH2:1].[OH2:2].[Sn:3]([Cl:4])([Cl:5])([Cl:6])[Cl:7]>>[Cl:8][c:9]1[cH:10][n:11][cH:12][c:13]([C:15]#[C:16][c:17]2[cH:18][c:19]([NH2:24])[c:20]([F:23])[cH:21][cH:22]2)[cH:14]1

Participants

6

Reactant 5

HCID 702EthanolHCID 962Water2×HCID 8028TetrahydrofuranHCID 24287Tin tetrachlorideHCID 670482143-Chloro-5-(4-fluoro-3-nitrophenylethynyl)-pyridine

Product 1

HCID 670475245-(5-Chloropyridin-3-ylethynyl)-2-fluorophenylamine

Sources & evidence

ORD record
ord-fe2959a12db7449eb42f2128de8050cc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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