Benzene → 3-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

HRID 936621Notes

Reaction equation

HRID 936621 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1.[CH2:12]([C:13]#[CH:14])[OH:15].[CH2:16]([NH:17][CH2:18][CH3:19])[CH3:20].[Cu:27][I:28].[cH:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1>>[c:2]1([C:14]#[C:13][CH2:12][OH:15])[cH:3][cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 241BenzeneHCID 7859Propargyl alcoholHCID 8021DiethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

Product 1

HCID 118304283-(4-(Trifluoromethyl)phenyl)prop-2-yn-1-ol

Sources & evidence

ORD record
ord-64431cedf3944b119097d697e67dd67b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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