Acetic Acid → Methyl 3-(cyclopentylamino)-2,2-difluoropropanoate

HRID 936760Notes

Reaction equation

HRID 936760 reaction equation
[C:16]([O:17][BH-:18]([O:19][C:20](=[O:21])[CH3:22])[O:23][C:24](=[O:25])[CH3:26])(=[O:27])[CH3:28].[C:41]([OH:42])(=[O:43])[CH3:44].[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40].[NH2:1][CH2:2][C:3]([C:4](=[O:5])[O:6][CH3:7])([F:8])[F:9].[Na+:29].[Na+:34].[O-:30][C:31]([OH:32])=[O:33].[O:10]=[C:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1>>[NH:1]([CH2:2][C:3]([C:4](=[O:5])[O:6][CH3:7])([F:8])[F:9])[CH:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 8028TetrahydrofuranHCID 8452CyclopentanoneHCID 8857Ethyl AcetateHCID 2724942TriacetoxyborohydrideHCID 22635306HCID 22635306, compound

Product 1

HCID 67117821Methyl 3-(cyclopentylamino)-2,2-difluoropropanoate

Sources & evidence

ORD record
ord-c54e5284d07548b08333120f42e064ba
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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