Water → 4-[2-(2,4-dichlorophenyl)-5-methyl-4-[(piperidin-1-ylamino)carbonyl]-1H-imidazol-1-yl]phenyl thiophene-2-sulfonate

HRID 937391Notes

Reaction equation

HRID 937391 reaction equation
[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[Cl:1][c:2]1[c:3](-[c:9]2[n:10](-[c:24]3[cH:25][cH:26][c:27]([OH:30])[cH:28][cH:29]3)[c:11]([CH3:23])[c:12]([C:14](=[O:15])[NH:16][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)[n:13]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1.[Cl:48][CH2:49][Cl:50].[OH2:47].[s:38]1[c:39]([S:43](=[O:44])(=[O:45])[Cl:46])[cH:40][cH:41][cH:42]1>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10](-[c:24]3[cH:25][cH:26][c:27]([O:30][S:43]([c:39]4[s:38][cH:42][cH:41][cH:40]4)(=[O:44])=[O:45])[cH:28][cH:29]3)[c:11]([CH3:23])[c:12]([C:14](=[O:15])[NH:16][N:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)[n:13]2)[cH:4][cH:5][c:6]([Cl:8])[cH:7]1

Participants

6

Reactant 5

HCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 855182-Thiophenesulfonyl chlorideHCID 589650752-(2,4-Dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylic acid piperidin-1-ylamide

Product 1

HCID 115052744-[2-(2,4-dichlorophenyl)-5-methyl-4-[(piperidin-1-ylamino)carbonyl]-1H-imidazol-1-yl]phenyl thiophene-2-sulfonate

Sources & evidence

ORD record
ord-656dcaa79f594da294b60d194a2f5950
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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