Tetrahydrofuran → 1-Benzyl-4-phenylpiperidine-4-methylamine

HRID 937534Notes

Reaction equation

HRID 937534 reaction equation
[Al+3:23].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([C:14]#[N:15])([c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[CH2:12][CH2:13]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][NH2:15])([c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 1914081-Benzyl-4-cyano-4-phenylpiperidine

Product 1

HCID 8042381-Benzyl-4-phenylpiperidine-4-methylamine

Sources & evidence

ORD record
ord-52feb82ab18d4e8ab7b5da7306e74751
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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