Dimethylformamide → Ethyl 8-(benzyloxy)-2-(4-fluorobenzyl)-1-oxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]-pyrazine-7-carboxylate

HRID 937792Notes

Reaction equation

HRID 937792 reaction equation
[Br:31][CH2:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[C:25](=[O:26])([O-:27])[O-:28].[Cs+:29].[Cs+:30].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:22])[c:9]3[n:10]([cH:13][c:14]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:15]3[OH:16])[CH2:11][CH2:12]2)[cH:23][cH:24]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:22])[c:9]3[n:10]([cH:13][c:14]([C:17](=[O:18])[O:19][CH2:20][CH3:21])[c:15]3[O:16][CH2:32][c:33]3[cH:34][cH:35][cH:36][cH:37][cH:38]3)[CH2:11][CH2:12]2)[cH:23][cH:24]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 3011068Ethyl 2-[(4-fluorophenyl)methyl]-8-hydroxy-1-oxo-3,4-dihydropyrrolo[1,2-a]pyrazine-7-carboxylate

Product 1

HCID 68864638Ethyl 8-(benzyloxy)-2-(4-fluorobenzyl)-1-oxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]-pyrazine-7-carboxylate

Sources & evidence

ORD record
ord-5fed98a4f8e44b208fff35578a057167
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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