Tetrahydrofuran → 6-(4-Fluorophenyl)-3-[1-[4-(hydroxymethyl)phenyl]ethyl]-6-(3-hydroxypropyl)-1,3-oxazinan-2-one
Reaction equation
[Al+3:32].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH2:27][CH2:28][CH2:29][OH:30])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20]([C:21](=[O:22])[O:23][CH3:24])[cH:25][cH:26]3)[C:12](=[O:14])[O:13]2)[cH:6][cH:7]1.[H-:31].[H-:34].[H-:35].[H-:36].[Li+:33]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH2:27][CH2:28][CH2:29][OH:30])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20]([CH2:21][OH:22])[cH:25][cH:26]3)[C:12](=[O:14])[O:13]2)[cH:6][cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-d2037f4d600d4c83910ca15615c7dbc8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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