Tetrahydrofuran → 3,5-Difluorobenzyl isothiocyanate

HRID 938270Notes

Reaction equation

HRID 938270 reaction equation

[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[Cl:18][C:19]([Cl:20])=[S:21].[F:1][c:2]1[cH:3][c:4]([CH2:5][NH2:6])[cH:7][c:8]([F:10])[cH:9]1.[O:22]1[CH2:23][CH2:24][CH2:25][CH2:26]1>>[F:1][c:2]1[cH:3][c:4]([CH2:5][N:6]=[C:19]=[S:21])[cH:7][c:8]([F:10])[cH:9]1

Participants

5

Reactant 4

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 10040Thiophosgene

HCID 1452113,5-Difluorobenzylamine

Product 1

HCID 201291633,5-Difluorobenzyl isothiocyanate

Sources & evidence

ORD record: ord-7e4fce7ef0364414a9c0919861d14d8c
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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