3-Bromopyridine → 6-(3-Fluorophenyl)-N-pyridin-3-yl-5-pyridin-4-ylpyrazin-2-amine

HRID 938368Notes

Reaction equation

HRID 938368 reaction equation
[Br:21][c:22]1[cH:23][n:24][cH:25][cH:26][cH:27]1.[C:70](=[O:71])([O-:72])[O-:73].[CH3:28][C:29]1([CH3:30])[c:31]2[cH:32][cH:33][cH:34][c:35]([P:36]([c:37]3[cH:38][cH:39][cH:40][cH:41][cH:42]3)[c:43]3[cH:44][cH:45][cH:46][cH:47][cH:48]3)[c:49]2[O:50][c:51]2[c:52]1[cH:53][cH:54][cH:55][c:56]2[P:57]([c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1)[c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1.[Cs+:74].[Cs+:75].[F:1][c:2]1[cH:3][c:4](-[c:8]2[c:9](-[c:15]3[cH:16][cH:17][n:18][cH:19][cH:20]3)[n:10][cH:11][c:12]([NH2:14])[n:13]2)[cH:5][cH:6][cH:7]1.[O:76]1[CH2:77][CH2:78][O:79][CH2:80][CH2:81]1>>[F:1][c:2]1[cH:3][c:4](-[c:8]2[c:9](-[c:15]3[cH:16][cH:17][n:18][cH:19][cH:20]3)[n:10][cH:11][c:12]([NH:14][c:22]3[cH:23][n:24][cH:25][cH:26][cH:27]3)[n:13]2)[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 122863-BromopyridineHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 160715396-(3-Fluorophenyl)-5-pyridin-4-ylpyrazin-2-amine

Product 1

HCID 160718986-(3-Fluorophenyl)-N-pyridin-3-yl-5-pyridin-4-ylpyrazin-2-amine

Sources & evidence

ORD record
ord-ace2cdf65a6b4ebc93e362ae8c36b3d2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…