Trifluoroacetic acid → 2-(3-Methoxy-phenyl)-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid methyl ester
Reaction equation
[CH2:26]([SiH:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH3:32].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[NH:11][CH:10]([c:15]1[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][cH:20]1)[C:9]([CH3:23])([CH3:24])[CH:8]2[OH:25].[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[NH:11][CH:10]([c:15]1[cH:16][c:17]([O:21][CH3:22])[cH:18][cH:19][cH:20]1)[C:9]([CH3:23])([CH3:24])[CH2:8]2Participants
4
Sources & evidence
- ORD record
- ord-ee0e5f0fb0874f659c0d7ac2ce2cbfdb
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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