1,2-Dichloroethane → {4-[6-(trans-4-tert-Butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-yl]-2-methyl-4,5-dihydro-oxazol-4-yl}-methanol

HRID 938592Notes

Reaction equation

HRID 938592 reaction equation
[C:33]([CH3:34])([O:35][CH2:36][CH3:37])([O:38][CH2:39][CH3:40])[O:41][CH2:42][CH3:43].[CH3:44][C:45](=[O:46])[OH:47].[Cl:48][CH2:49][CH2:50][Cl:51].[ClH:32].[NH2:1][C:2]([CH2:3][OH:4])([CH2:5][OH:6])[c:7]1[cH:8][c:9]2[cH:10][cH:11][c:12]([O:21][CH:22]3[CH2:23][CH2:24][CH:25]([C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:26][CH2:27]3)[c:13]([C:17]([F:18])([F:19])[F:20])[c:14]2[cH:15][cH:16]1>>[N:1]1=[C:33]([CH3:34])[O:4][CH2:3][C:2]1([CH2:5][OH:6])[c:7]1[cH:8][c:9]2[cH:10][cH:11][c:12]([O:21][CH:22]3[CH2:23][CH2:24][CH:25]([C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:26][CH2:27]3)[c:13]([C:17]([F:18])([F:19])[F:20])[c:14]2[cH:15][cH:16]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 66221Triethyl orthoacetateHCID 674250532-Amino-2-[6-(4-tert-butylcyclohexyl)oxy-5-(trifluoromethyl)naphthalen-2-yl]propane-1,3-diol

Product 1

HCID 67530443{4-[6-(trans-4-tert-Butyl-cyclohexyloxy)-5-trifluoromethyl-naphthalen-2-yl]-2-methyl-4,5-dihydro-oxazol-4-yl}-methanol

Sources & evidence

ORD record
ord-8c85be1140b047c0be96b36b85fc1c5f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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