Hydrochloric Acid → 3-[4-(Trifluoromethyl)anilino]pentanoic acid

HRID 938607Notes

Reaction equation

HRID 938607 reaction equation
[Br:9][c:10]1[cH:11][cH:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]1.[C:20](=[O:21])([O-:22])[O-:23].[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[CH3:38][S:39]([CH3:40])=[O:41].[ClH:26].[Cu:27]([I:28])[I:29].[K+:24].[K+:25].[NH2:1][CH:2]([CH2:3][C:4](=[O:5])[OH:6])[CH2:7][CH3:8].[OH2:37]>>[NH:1]([CH:2]([CH2:3][C:4](=[O:5])[OH:6])[CH2:7][CH3:8])[c:10]1[cH:11][cH:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]1

Participants

10

Reactant 9

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 1140TolueneHCID 19660Carbonate IonHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 83717Copper iodideHCID 147319783-Aminopentanoic acid

Product 1

HCID 211060443-[4-(Trifluoromethyl)anilino]pentanoic acid

Sources & evidence

ORD record
ord-227fe7a40eef425683f28ed0dc073374
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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