Acetic Acid → Tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

HRID 939006Notes

Reaction equation

HRID 939006 reaction equation
[C:33](=[O:34])([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[N:40]1[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]1.[CH3:46][C:47](=[O:48])[OH:49].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[CH3:56][N:57]1[CH2:58][CH2:59][CH2:60][C:61]1=[O:62].[CH:1]1([NH:4][C:5](=[O:6])[NH:7][c:8]2[cH:9][c:10]([F:32])[c:11]([O:14][c:15]3[c:16]4[c:17]([n:18][cH:19][cH:20]3)[cH:21][c:22](-[c:24]3[n:25][cH:26][c:27]([CH:30]=[O:31])[cH:28][cH:29]3)[s:23]4)[cH:12][cH:13]2)[CH2:2][CH2:3]1>>[CH:1]1([NH:4][C:5](=[O:6])[NH:7][c:8]2[cH:9][c:10]([F:32])[c:11]([O:14][c:15]3[c:16]4[c:17]([n:18][cH:19][cH:20]3)[cH:21][c:22](-[c:24]3[n:25][cH:26][c:27]([CH2:30][N:43]5[CH2:42][CH2:41][N:40]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:45][CH2:44]5)[cH:28][cH:29]3)[s:23]4)[cH:12][cH:13]2)[CH2:2][CH2:3]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 8857Ethyl AcetateHCID 13387N-methyl-2-pyrrolidoneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 582365791-Cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Product 1

HCID 67441338Tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-a2c0ca58f37b4ab191a05ee5bf310930
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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