Diethyl Ether → tert-butyl 4-{3-[3-(3,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]propyl}piperazine-1-carboxylate

HRID 939276Notes

Reaction equation

HRID 939276 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][N:5]1[S:6](=[O:22])(=[O:23])[N:7]([c:14]2[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]2)[c:8]2[c:9]1[cH:10][cH:11][cH:12][cH:13]2.[CH2:51]([O:52][CH2:53][CH3:54])[CH3:55].[CH3:46][N:47]([CH3:48])[CH:49]=[O:50].[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[N:24]1([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1>>[CH2:2]([CH2:3][CH2:4][N:5]1[S:6](=[O:22])(=[O:23])[N:7]([c:14]2[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]2)[c:8]2[c:9]1[cH:10][cH:11][cH:12][cH:13]2)[N:27]1[CH2:26][CH2:25][N:24]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:29][CH2:28]1

Participants

6

Reactant 5

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 687126561-(3-Bromopropyl)-3-(3,4-difluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Product 1

HCID 68709886tert-butyl 4-{3-[3-(3,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]propyl}piperazine-1-carboxylate

Sources & evidence

ORD record
ord-96a082b9f570457bbfa4a3b60461cc47
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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