Dimethylformamide → 1-(6-Chloropyrimidin-4-yl)-1-methyl-3-(2-methyl-5-nitrophenyl)urea

HRID 939375Notes

Reaction equation

HRID 939375 reaction equation
[CH3:10][c:11]1[c:12]([N:20]=[C:21]=[O:22])[cH:13][c:14]([N+:17](=[O:18])[O-:19])[cH:15][cH:16]1.[CH:23]([N:24]([CH2:25][CH3:26])[CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[cH:3][c:4]([NH:8][CH3:9])[n:5][cH:6][n:7]1.[O:32]=[CH:33][N:34]([CH3:35])[CH3:36]>>[Cl:1][c:2]1[cH:3][c:4]([N:8]([CH3:9])[C:21]([NH:20][c:12]2[c:11]([CH3:10])[cH:16][cH:15][c:14]([N+:17](=[O:18])[O-:19])[cH:13]2)=[O:22])[n:5][cH:6][n:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 2926092-Methyl-5-nitrophenyl isocyanateHCID 3094796-chloro-N-methylpyrimidin-4-amine

Product 1

HCID 577103271-(6-Chloropyrimidin-4-yl)-1-methyl-3-(2-methyl-5-nitrophenyl)urea

Sources & evidence

ORD record
ord-191a8b17a46241cb8216286af90a3298
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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