Tetrahydrofuran → 1'-(diphenylmethyl)-5,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 940248Notes

Reaction equation

HRID 940248 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[Cl:39][CH2:40][I:41].[Cs+:37].[Cs+:38].[F:1][c:2]1[cH:3][c:4]([OH:32])[c:5]([CH:9]2[C:10](=[O:31])[N:11]([CH:18]([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[cH:6][c:7]1[F:8].[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[F:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][c:7]1[F:8])[C:9]1([C:10](=[O:31])[N:11]([CH:18]([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[c:25]3[cH:26][cH:27][cH:28][cH:29][cH:30]3)[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]31)[CH2:33][O:32]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11644ChloroiodomethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 673572403-(4,5-difluoro-2-hydroxyphenyl)-1-(diphenylmethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 593520761'-(diphenylmethyl)-5,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d3c6e48e0aef4b749ec154fb37e28560
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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