Hydrogen Bromide → N-[1-(5-chloro-2-pyridinyl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]-3,3-difluoropyrrolidine-1-carboxamide

HRID 940416Notes

Reaction equation

HRID 940416 reaction equation
[BrH:40].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)([c:16]2[cH:17][c:18]([F:26])[cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[NH:27][C:28]([O:29][c:30]2[cH:31][cH:32][c:33]([N+:34]([O-:35])=[O:36])[cH:37][cH:38]2)=[O:39])[n:6][cH:7]1.[F:41][C:42]1([F:47])[CH2:43][NH:44][CH2:45][CH2:46]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH2:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)([c:16]2[cH:17][c:18]([F:26])[cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]2)[NH:27][C:28](=[O:39])[N:44]2[CH2:43][C:42]([F:41])([F:47])[CH2:46][CH2:45]2)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 27828273,3-DifluoropyrrolidineHCID 66934387(4-nitrophenyl) N-[1-(5-chloro-2-pyridinyl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]carbamate

Product 1

HCID 72463281N-[1-(5-chloro-2-pyridinyl)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-phenylethyl]-3,3-difluoropyrrolidine-1-carboxamide

Sources & evidence

ORD record
ord-142be41a74e64b6aabb8fa12989d3551
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…