Dimethylformamide → 4-(4-Difluoromethyl-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide
Reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]([CH:29]([F:30])[F:31])[cH:27][cH:28]1.[C:32](=[O:33])([O-:34])[O-:35].[CH3:1][n:2]1[n:3][c:4]([NH:7][C:8](=[O:9])[c:10]2[cH:11][c:12]3[c:13]([c:19]([OH:21])[cH:20]2)[CH2:14][C:15]([CH3:17])([CH3:18])[O:16]3)[cH:5][cH:6]1.[Cs+:36].[Cs+:37].[Cu:43][I:44].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[CH3:1][n:2]1[n:3][c:4]([NH:7][C:8](=[O:9])[c:10]2[cH:11][c:12]3[c:13]([c:19]([O:21][c:23]4[cH:24][cH:25][c:26]([CH:29]([F:30])[F:31])[cH:27][cH:28]4)[cH:20]2)[CH2:14][C:15]([CH3:17])([CH3:18])[O:16]3)[cH:5][cH:6]1Participants
7
Reactant 6
HCID 6228Dimethylformamide
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 104967Cesium cation2×
HCID 27611831-Bromo-4-(difluoromethyl)benzene
HCID 595600842,3-Dihydro-4-hydroxy-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)-6-benzofurancarboxamideProduct 1
Sources & evidence
- ORD record
- ord-4ea4f29784ad4b4e87c1cab86ff55545
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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