Methanol → 4-(Tert-butoxycarbonylamino)-2-(4-chlorophenyl)-4-methylpentanoic acid

HRID 940797Notes

Reaction equation

HRID 940797 reaction equation
[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[CH3:31][OH:32].[Cl:4][c:5]1[cH:6][cH:7][c:8]([CH:11]2[CH2:12][C:13]([CH3:24])([CH3:25])[N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[C:15]2=[O:16])[cH:9][cH:10]1.[Li+:3].[OH-:2].[OH2:1].[OH2:33]>>[OH:1][C:15]([CH:11]([c:8]1[cH:7][cH:6][c:5]([Cl:4])[cH:10][cH:9]1)[CH2:12][C:13]([NH:14][C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])([CH3:24])[CH3:25])=[O:16]

Participants

7

Reactant 6

HCID 887MethanolHCID 961HydroxideHCID 962Water2×HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 66617851Tert-butyl 4-(4-chlorophenyl)-2,2-dimethyl-5-oxopyrrolidine-1-carboxylate

Product 1

HCID 666178284-(Tert-butoxycarbonylamino)-2-(4-chlorophenyl)-4-methylpentanoic acid

Sources & evidence

ORD record
ord-436fd29f73d8421fb177e581d302940b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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