Tetrahydrofuran → (2-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-4-trifluoromethyl-phenyl)-cyclopentyl-methanol

HRID 940834Notes

Reaction equation

HRID 940834 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH:35]1([CH:40]=[O:41])[CH2:36][CH2:37][CH2:38][CH2:39]1.[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][n:10][n:11]([CH3:13])[n:12]2)[CH2:14][c:15]2[c:16]([Br:25])[cH:17][cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[cH:26][c:27]([C:29]([F:30])([F:31])[F:32])[cH:28]1)([F:33])[F:34]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][n:10][n:11]([CH3:13])[n:12]2)[CH2:14][c:15]2[c:16]([CH:40]([CH:35]3[CH2:36][CH2:37][CH2:38][CH2:39]3)[OH:41])[cH:17][cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[cH:26][c:27]([C:29]([F:30])([F:31])[F:32])[cH:28]1)([F:33])[F:34]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 70106CyclopentanecarbaldehydeHCID 58966468(3,5-bis-trifluoromethyl-benzyl)-(2-bromo-5-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)amine

Product 1

HCID 58968659(2-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-4-trifluoromethyl-phenyl)-cyclopentyl-methanol

Sources & evidence

ORD record
ord-d0560cd5e5f94387b2d97a615bf779f7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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