Dimethylformamide → Tert-butyl 3-bromo-1-[[4-methyl-1-(methylamino)-1-oxopentan-2-yl]carbamoyl]-5,6,7,9-tetrahydroimidazo[1,5-a][1,4]diazepine-8-carboxylate

HRID 941019Notes

Reaction equation

HRID 941019 reaction equation
[B-:41]([F:42])([F:43])([F:44])[F:45].[Br:1][c:2]1[n:3][c:4]([C:19](=[O:20])[OH:21])[c:5]2[n:6]1[CH2:7][CH2:8][CH2:9][N:10]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:11]2.[CH3:22][NH:23][C:24]([CH:25]([NH2:26])[CH2:27][CH:28]([CH3:29])[CH3:30])=[O:31].[CH:32]([N:33]([CH2:34][CH3:35])[CH:36]([CH3:37])[CH3:38])([CH3:39])[CH3:40].[O:63]=[CH:64][N:65]([CH3:66])[CH3:67].[n:46]1([O:47][C:48]([N:49]([CH3:50])[CH3:51])=[N+:52]([CH3:53])[CH3:54])[c:55]2[cH:56][cH:57][cH:58][cH:59][c:60]2[n:61][n:62]1>>[Br:1][c:2]1[n:3][c:4]([C:19](=[O:20])[NH:26][CH:25]([C:24]([NH:23][CH3:22])=[O:31])[CH2:27][CH:28]([CH3:29])[CH3:30])[c:5]2[n:6]1[CH2:7][CH2:8][CH2:9][N:10]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:11]2

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 142849542-amino-N,4-dimethylpentanamideHCID 576352073-bromo-8-(tert-butoxycarbonyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxylic acid

Product 1

HCID 66931879Tert-butyl 3-bromo-1-[[4-methyl-1-(methylamino)-1-oxopentan-2-yl]carbamoyl]-5,6,7,9-tetrahydroimidazo[1,5-a][1,4]diazepine-8-carboxylate

Sources & evidence

ORD record
ord-0a7e40ce0771449bbf8db087e480c4a1
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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