Sodium ion → Tert-butyl 4-cyano-4-(pyridin-2-YL)piperidine-1-carboxylate

HRID 941316Notes

Reaction equation

HRID 941316 reaction equation
[C:1](#[N:2])[CH:3]1[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:23][Si:24]([N-:25][Si:26]([CH3:27])([CH3:28])[CH3:29])([CH3:30])[CH3:31].[F:16][c:17]1[n:18][cH:19][cH:20][cH:21][cH:22]1.[Na+:32]>>[C:1](#[N:2])[C:3]1([c:17]2[n:18][cH:19][cH:20][cH:21][cH:22]2)[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 97462-FluoropyridineHCID 1514443Tert-butyl 4-cyanopiperidine-1-carboxylateHCID 3280088Npc316347

Product 1

HCID 53439111Tert-butyl 4-cyano-4-(pyridin-2-YL)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-6d0ec0b8003b4545ad49e1eef2fce268
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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