Tetrahydrofuran → Nilutamide EP impurity A

HRID 941740Notes

Reaction equation

HRID 941740 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[F:8][C:9]([c:10]1[cH:11][c:12]([N:19]=[C:20]=[O:21])[cH:13][cH:14][c:15]1[N+:16](=[O:17])[O-:18])([F:22])[F:23].[NH2:24][C:25]([CH3:26])([CH3:27])[C:28]#[N:29].[O:30]1[CH2:31][CH2:32][CH2:33][CH2:34]1>>[F:8][C:9]([c:10]1[cH:11][c:12]([N:19]2[C:20](=[O:21])[NH:24][C:25]([CH3:26])([CH3:27])[C:28]2=[NH:29])[cH:13][cH:14][c:15]1[N+:16](=[O:17])[O-:18])([F:22])[F:23]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 880222-Amino-2-methylpropionitrileHCID 153425614-Isocyanato-1-nitro-2-(trifluoromethyl)benzene

Product 1

HCID 15342562Nilutamide EP impurity A

Sources & evidence

ORD record
ord-cd85ec145e20412d8ff7b043e8493c1f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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